Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur
There is a level 4 bio lab in Wuhan, with well-documented safety issues, that did an immense amount of research into coronavirus from bats. It’s stupid to say this is a synthetic virus, but a lab accident is certainly plausible.
Just to clarify, a man made virus isn’t possible because the RNA sequence is too complicated to have been made in a lab. A naturally occurring virus that was accidentally leaked is FAR more likely.
Geneticist are saying, Indeed, the closest known relative to human SARS-CoV-2 was published by the Wuhan lab (RaTG13), but it is separated by years of mutations. Notably, the Wuhan lab did sampling of bat SARS-CoV strains, with many strains being unpublished so far (nature news describing this work). They also conducted and published experiments with human ACE2 cell cultures, conducted in Wuhan, artificially crossing the species barrier using large amounts of virus.
They locked down Wuhan (before airborne transmission proven), they were rounding up domestic pets (before we knew animals could get it), and whistle blowers have been disappeared.
I think they still know more about this virus than they’re letting on because they were studying it, which is also why they reacted in a way that is constant with them knowing certain things before they should have been able if they weren’t lying to us all
Check the date of the article – December 2017
– https://www.nature.com/articles/d41586-017-07766-9?fbclid=IwAR248CznybWr518iNuoCw34nh7pCjHWGGnQwaMa3-A9jgQ4eiNIvQNnztVE
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Chinese scientists find all the genetic building blocks of SARS in a single population of horseshoe bats.
After a detective hunt across China, researchers chasing the origin of the deadly SARS virus have finally found their smoking gun. In a remote cave in Yunnan province, virologists have identified a single population of horseshoe bats that harbours virus strains with all the genetic building blocks of the one that jumped to humans in 2002, killing almost 800 people around the world.
The killer strain could easily have arisen from such a bat population, the researchers report in PLoS Pathogens1 on 30 November. They warn that the ingredients are in place for a similar disease to emerge again.
In late 2002, cases of a mystery pneumonia-like illness began occurring in Guangdong province, southeastern China. The disease, dubbed severe acute respiratory syndrome (SARS), triggered a global emergency as it spread around the world in 2003, infecting thousands of people.
Scientists identified the culprit as a strain of coronavirus and found genetically similar viruses in masked palm civets (Paguma larvata) sold in Guangdong’s animal markets. Later surveys revealed large numbers of SARS-related coronaviruses circulating in China’s horseshoe bats (Rhinolophus)2 — suggesting that the deadly strain probably originated in the bats, and later passed through civets before reaching humans. But crucial genes — for a protein that allows the virus to latch onto and infect cells — were different in the human and known bat versions of the virus, leaving room for doubt about this hypothesis.
Bat hunt
To clinch the case, a team led by Shi Zheng-Li and Cui Jie of the Wuhan Institute of Virology in China sampled thousands of horseshoe bats in locations across the country3. “The most challenging work is to locate the caves, which usually are in remote areas,” says Cui. After finding a particular cave in Yunnan, southwestern China, in which the strains of coronavirus looked similar to human versions4,5, the researchers spent five years monitoring the bats that lived there, collecting fresh guano and taking anal swabs1.Inside the Chinese lab poised to study world’s most dangerous pathogens
They sequenced the genomes of 15 viral strains from the bats and found that, taken together, the strains contain all the genetic pieces that make up the human version. Although no single bat had the exact strain of SARS coronavirus that is found in humans, the analysis showed that the strains mix often. The human strain could have emerged from such mixing, says Kwok-Yung Yuen, a virologist at the University of Hong Kong who co-discovered the SARS virus: “The authors should be congratulated for confirming what has been suspected.”
But Changchun Tu, a virologist who directs the OIE Reference Laboratory for Rabies in Changchun, China, says the results are only “99%” persuasive. He would like to see scientists demonstrate in the lab that the human SARS strain can jump from bats to another animal, such as a civet. “If this could have been done, the evidence would be perfect,” he says.
Travel trouble
Another outstanding question is how a virus from bats in Yunnan could travel to animals and humans around 1,000 kilometres away in Guangdong, without causing any suspected cases in Yunnan itself. That “has puzzled me a long time”, says Tu.
Cui and Shi are searching for other bat populations that could have produced strains capable of infecting humans. The researchers have now isolated some 300 bat coronavirus sequences, most not yet published, with which they will continue to monitor the virus’s evolution.
And they warn that a deadly outbreak could emerge again: the cave where the elements of SARS were found is just 1 kilometre from the nearest village, and genetic mixing among the viral strains is fast. “The risk of spillover into people and emergence of a disease similar to SARS is possible,” the authors write in their paper.
Although many markets selling animals in China have already been closed or restricted following outbreaks of SARS and other infectious diseases, Yuen agrees that the latest results suggest the risk is still present. “It reinforces the notion that we should not disturb wildlife habitats and never put wild animals into markets,” says Yuen. Respecting nature, he argues, “is the way to stay away from the harm of emerging infections”.
Date Posted, 15-16 (2017)
